Cartwheel assembly

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Cartwheel assembly

The cartwheel is a subcentriolar structure consisting of a central hub and nine radially arranged spokes, located at the proximal end of the centriole. It appears at the initial stage of the centriole assembly process as the first ninefold symmetrical structure. The cartwheel was first described more than 50 years ago, but it is only recently that its pivotal role in establishing the ninefold s...

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Cell-free reconstitution reveals centriole cartwheel assembly mechanisms

How cellular organelles assemble is a fundamental question in biology. The centriole organelle organizes around a nine-fold symmetrical cartwheel structure typically ∼100 nm high comprising a stack of rings that each accommodates nine homodimers of SAS-6 proteins. Whether nine-fold symmetrical ring-like assemblies of SAS-6 proteins harbour more peripheral cartwheel elements is unclear. Furtherm...

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Cartwheel: Tools for Regulatory Genomics

Understanding gene regulation in detail is a goal of both developmental biology and microbial physiology, yet computational tools for investigating the function of non-coding sequence remain relatively immature. Simple, intuitive, and powerful tools that allow individual bench biologists to explore regulatory function in genomic sequence can dramatically increase experimental productivity by bo...

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Bld10p, a novel protein essential for basal body assembly in Chlamydomonas : localization to the cartwheel, the first ninefold symmetrical structure appearing during assembly

ow centrioles and basal bodies assemble is a longstanding puzzle in cell biology. To address this problem, we analyzed a novel basal body-defective Chlamydomonas reinhardtii mutant isolated from a collection of flagella-less mutants. This mutant, bld10 , displayed disorganized mitotic spindles and cytoplasmic microtubules, resulting in abnormal cell division and slow growth. Electron microscopi...

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Interferometric Performance of a Cartwheel Constellation for TerraSAR-L

This paper provides a prediction of the achievable interferometric performance for a TerraSAR-L cartwheel constellation. Assuming receiving antennas of only 3m diameter, ambiguity and noise floor levels are analysed in detail. Expected DEM accuracies for different effective baselines at different swath positions including effects of local slope and volume decorrelation over vegetation are prese...

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ژورنال

عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences

سال: 2014

ISSN: 0962-8436,1471-2970

DOI: 10.1098/rstb.2013.0458